Synthesis of Isoxazoles and Quinoxalines as Potential Anticancer Agents

Autor:	Arun Parikh, N. A. Vekariya, M. D. Khunt
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Chemistry Yield (chemistry) Diamine Proton NMR Organic chemistry General Medicine Spectral data Antimicrobial Sodium acetate Derivative (chemistry) Thin-layer chromatography
Zdroj:	ChemInform. 34
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200322165
Popis:	2-Acetylbenzimidazole on condensation with various aldehydes yield chalcones 1 which on cyclisation with hydroxylamine hydrochloride in sodium acetate furnish 3-(benzimidazol-2'-yl)-5-arylisoxazoles 2a-1. Dibromo derivative of chalcones 1 on reaction with 2-phenylene diamine in sulphuric acid furnish 2-(benzimidazol-2'-yl-methyl)-3-arylquinoxalines 3a-1. The structure of the compounds 3a-1 have been confirmed from elemental analyses, IR, 1 H NMR and mass spectral data. The purity of the synthesised compounds have been checked by thin layer chromatography and screened for their antimicrobial and anticancer activity. All the products have been evaluated for their in vitro growth inhibitory activity against different microbes.
Databáze:	OpenAIRE
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