Development of Nelson's syndrome in a patient with recurrent cushing's disease
| Autor: | Rachelle N. Bitton, Ronald Cobbs, Bruce Schneider |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
endocrine system
medicine.medical_specialty Pituitary gland business.industry Pituitary tumors Nelson's syndrome Cushingoid General Medicine Nelson Syndrome Cushing's disease medicine.disease Cushing syndrome Hypercortisolemia medicine.anatomical_structure Endocrinology Internal medicine medicine business |
| Zdroj: | The American Journal of Medicine. 84:319-324 |
| ISSN: | 0002-9343 |
| Popis: | A markedly cushingoid 32-year-old man presented to Queens Hospital Center with headache, hyperpigmentation, and visual field loss. Twelve years earlier, he had undergone subtotal adrenalectomy for Cushing's disease, but symptoms of hypercortisolemia promptly recurred. Workup revealed the presence of a large, expanding intrasellar mass, plasma ACTH levels between 3,000 and 10,000 pg/ml, and markedly elevated cortisol levels. The secretion of ACTH (mainly ACTH 1-39-like peptide) by the pituitary tumor showed neither diurnal periodicity nor response to a variety of pharmacologic agents known to affect ACTH secretion. The patient demonstrates a rarely observed presentation of Nelson's syndrome, with aggressive adrenotropic pituitary tumor growth even in the presence of chronic hypercortisolemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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