4-hydroxy-2- quinolones 199*. use of N,N'-dicyclohexylcarbodiimide in the synthesis of ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates

Autor:	N. Yu. Golik, O. V. Bevz, O. V. Gorokhova, Igor V. Ukrainets
Rok vydání:	2011
Předmět:	N N-Dicyclohexylcarbodiimide Acylation chemistry.chemical_compound Monoethyl malonate chemistry Organic Chemistry Organic chemistry Dieckmann condensation
Zdroj:	Chemistry of Heterocyclic Compounds. 47:833-837
ISSN:	1573-8353 0009-3122
Popis:	A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2-dihydroquinoline3-carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f733ff446c6f9d0801f779bf1ddfb42 https://doi.org/10.1007/s10593-011-0843-8 Zobrazit plný text záznamu Plný text ve formátu PDF