Subcutaneous fat mass in infancy and cardiovascular risk factors at school-age: The generation R study
| Autor: | Andreia Oliveira, Romy Gaillard, Oscar H. Franco, Susana Santos, Albert Hofman, Henrique Barros, Vincent W. V. Jaddoe |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population Medicine (miscellaneous) Blood lipids Adipose tissue 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Classification of obesity Internal medicine medicine 030212 general & internal medicine education Prospective cohort study 2. Zero hunger education.field_of_study Nutrition and Dietetics Cholesterol business.industry medicine.disease Obesity chemistry business Body mass index |
| Zdroj: | Obesity. 24:424-429 |
| ISSN: | 1930-7381 |
| Popis: | Objective To examine the associations of infant subcutaneous fat with cardiovascular risk factors at school-age. Methods In a population-based prospective cohort study among 808 children, total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total subcutaneous fat) at 1.5 and 24 months were estimated. At 6 years, body mass index, blood pressure, cholesterol, triglycerides, and insulin levels were measured. Results Infant subcutaneous fat measures were not associated with childhood blood pressure, triglycerides, or insulin levels. A 1-standard-deviation score (SDS) higher total subcutaneous fat at 1.5 months was, independently of body mass index, associated with lower low-density lipoprotein (LDL)-cholesterol levels at 6 years. In contrast, a 1-SDS higher total subcutaneous fat at 24 months was associated with higher total-cholesterol [difference 0.13 (95% confidence interval (CI) 0.03, 0.23) SDS] and LDL-cholesterol levels [difference 0.12 (95% CI 0.02, 0.21) SDS] at 6 years. There were no associations of central-to-total subcutaneous fat ratio with childhood cholesterol levels. Conclusions These results suggest that infant total subcutaneous fat is weakly associated with cholesterol levels at school-age. Further studies are needed to assess the long-term cardiometabolic consequences of infant body fat. |
| Databáze: | OpenAIRE |
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