γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine: a new amphoteric and reusable magnetic nanocatalyst for the synthesis of new pyrimidonaphthyridine derivatives and their antioxidant and antifungal activity evaluation
| Autor: | Younes Abbasi, Davood Azarifar, Fatemeh Ghasemlou, Masoumeh Ghaemi, Roya Karamian, Mostafa Asadbegy |
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| Rok vydání: | 2018 |
| Předmět: |
Thermogravimetric analysis
Nanocomposite 010405 organic chemistry Scanning electron microscope DPPH Nanoparticle General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Materials Chemistry Hydroxide Magnetic nanoparticles Fourier transform infrared spectroscopy Nuclear chemistry |
| Zdroj: | New Journal of Chemistry. 42:1796-1805 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c7nj03803h |
| Popis: | The synthesis of a novel layered double hydroxide (LDH)-based N-amidinoglycine-functionalized magnetic nanocomposite, γ-Fe2O3@Cu3Al-LDH-N-amidinoglycine, has been described. The structure of the synthesized nanoparticles was characterized by different physicochemical techniques such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM), and using a vibrating sample magnetometer (VSM). These newly developed magnetic nanoparticles have been explored as a magnetically separable amphoteric nanocatalyst for the synthesis of new pyrimido[4,5-b][1,8]naphthyridine-7-carbonitrile derivatives in excellent yields via one-pot three-component reaction between aldehydes, 3-cyano-6-hydroxy-4-methyl-pyridin-2(1H)-one, and N,N-dimethyl-6-aminouracil. In the subsequent part of the present research, these synthesized pyrimido[4,5-b][1,8]naphthyridines were evaluated for their antioxidant and antifungal activities in vitro by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and PDA (potato dextrose agar) medium, respectively. |
| Databáze: | OpenAIRE |
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