Hypothalamus-Specific Regulation of Gonadotropin- Releasing Hormone Gene Expression

Autor:	Pamela L. Mellon, Mark A. Lawson, David B. Whyte, Satish A. Eraly
Rok vydání:	1995
Předmět:	endocrine system medicine.medical_specialty Gonadotropin-releasing hormone Biology Gonadotropic cell Endocrinology nervous system Hypothalamus Internal medicine Forebrain Gene expression medicine Endocrine system Enhancer hormones hormone substitutes and hormone antagonists Hormone
DOI:	10.1016/b978-0-12-571150-0.50037-8
Popis:	Publisher Summary The gonadotropin-releasing hormone (GnRH)-producing neurons of the hypothalamus represent such a group of neurons that is refractory to direct study because of their low numbers and diffuse distribution within the rostral hypothalamus and forebrain. The GnRH releasing neurons are important regulators of the pituitary gonadotropes and the endocrine actions that regulate reproductive function. Most studies of these neurons are limited to in situ analyses with immunological or nucleic acid probes. The tissue-specific transcriptional activity of the GnRH gene is a result of the unique complement of DNA-binding proteins present in the GnRH-releasing neurons, which mediate specific gene expression through the GnRH enhancer. The characterization of these proteins and their regulation is essential to our understanding of the development and regulation of the differentiated functions of the GnRH-releasing neurosecretory neurons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f6aaa92a2a9f45bd5096b2254142439 https://doi.org/10.1016/b978-0-12-571150-0.50037-8 Zobrazit plný text záznamu