Effect of Methanol Extract of Polygonum minus on Neuropathic Pain and Cognitive Dysfunction in Rats

Autor:	Arunachalam Muthuraman, Parayil Varghese Christapher, Koay Hean Huat Jonathan, Liew Shi Zhang, Koh Sing Yap Jordon
Rok vydání:	2021
Předmět:	Nutrition and Dietetics business.industry Thiobarbituric acid Pregabalin Morris water navigation task Pharmacology Free radical scavenger Lipid peroxidation chemistry.chemical_compound chemistry Neuropathic pain Medicine Cholinergic Pharmacology (medical) Neurology (clinical) business Donepezil medicine.drug
Zdroj:	International Journal of Nutrition, Pharmacology, Neurological Diseases. 11:154
ISSN:	2231-0738
DOI:	10.4103/ijnpnd.ijnpnd_109_20
Popis:	Introduction: Polygonum minus is one of the traditional medicinal plants. It contains various bioactive ingredients such as flavonoids and essential oil. It possesses the potential pharmacological actions, cytotoxicity, and antiproliferative actions. The role of Polygonum minus on neuropathic pain and cognitive functions remains to be explored. The present study was designed to evaluate the role of methanolic extract of Polygonum minus (PM) in paclitaxel (PT) and scopolamine (SCO) induced neuropathic pain and cognitive dysfunction in rats respectively. Methods: The PT (2 mg/kg; i.p. for 10 days) and SCO (1 mg/kg; i.p. for 4 days) were used for the induction of neuropathic pain and cognitive dysfunction in rats. The PM (200 and 400 mg/kg; for 10 days) was used for testing neuro-analgesic effect and the PM (150 mg/kg; for 4 days) was used for cognitive function study. The neuropathic pain was assessed by plantar, tail immersion, and pinprick tests. The cognitive function was assessed by the Morris water maze test. The reference drugs, that is, pregabalin (10 mg/kg) and donepezil (1 mg/kg) used for the assessment of neuropathic pain and cognitive function. Besides, the hippocampal tissue samples were used for the estimation of acetylcholinesterase activity, thiobarbituric acid reactive substances, reduced glutathione, and total protein levels. Results: The administration of PM ameliorated the PT- and SCO-induced neuropathic pain and cognitive dysfunctions in a dose-dependent manner. Conclusion: The PM possesses the potential neuroprotective actions due to its potential antioxidant, lipid peroxidation inhibition, and regulation of cholinergic neurotransmitter functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f67c494952e193ed23c42ee050f765c https://doi.org/10.4103/ijnpnd.ijnpnd_109_20 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.