Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia

Autor:	Maha Abdullah, Saraiza Abu Bakar, Yap Yoke Yeow, Thanusha Karunakaran, Lee Sing Seng, Peyman Amini, Amir Hamzah Abdul Latiff, Seow Heng Fong, Norzhafarina Hani
Rok vydání:	2016
Předmět:	medicine.medical_specialty Allergy business.industry Ethnic group Symptom severity Disease medicine.disease SSS 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Otorhinolaryngology Quality of life Internal medicine Immunology Severity of illness Immunology and Allergy Medicine 030212 general & internal medicine Young adult business
Zdroj:	International Forum of Allergy & Rhinology. 6:624-630
ISSN:	2042-6976
Popis:	Background The number of available reports regarding the influence of ethnicity on clinical features of allergic rhinitis (AR), especially disease severity in tropical climates, is limited. We aimed to compare clinical parameters and disease severity in AR patients of different ethnicities. Methods Malay, Chinese, and Indian AR patients (n = 138) with confirmed sensitivity to Dermatophagoides pteronyssinus, Dematophagoides farinae, and Blomia tropicalis were tested for mite-specific immunoglobulin E (sIgE) levels. A detailed questionnaire was used to collect data on nasal symptom score (NSS), ocular symptom score (OSS), sum of symptoms score (SSS), quality of life score (QLS), symptomatic control score (SCS), and total sum of scores (TSS) and correlate the derived data with patients’ demography, mite-polysensitivity, and sIgE levels. Results AR-related symptoms were most severe in Malays and least in Chinese (p < 0.01). Age (r = 0.516 to 0.673, p < 0.05) and duration of AR (r = 0.635 to 0.726, p < 0.01) correlated positively with severity domains (NSS, SSS, QLS, and TSS) in Chinese. Duration of concurrent allergies was highest in Malays (p < 0.05). Polysensitivity predicted increased sIgE levels in Malays (r = 0.464 to 0.551, p < 0.01) and Indians (r = 0.541 to 0.645, p < 0.05) but affected NSS, SSS, and TSS only in Indians (r = 0.216 to 0.376, p < 0.05). sIgE levels were lowest among Chinese but correlated strongly with NSS, OSS, SSS, and TSS (r = 0408 to 0.898, p < 0.05). Conclusion Clinical parameters in AR may be influenced by race. Symptoms were most severe among Malays but did not correlate with other variables examined. Although Indian ethnicity did not impact disease severity, duration of concurrent allergies and mite-polysensitivity was associated with more severe disease. Age, duration of disease, and sIgE levels may be useful indicators of disease severity in Chinese.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f660c71f2ab892f40cd4ce52167357d https://doi.org/10.1002/alr.21442 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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