On the Coagulation of Platelet-Rich Plasma

Autor:	I. Keularts, S. Béguin
Rok vydání:	1999
Předmět:	biology Chemistry Hirudin Hematology Pharmacology Platelet membrane glycoprotein Thrombomodulin Fibrin Thrombin Physiology (medical) medicine biology.protein Glycoprotein Ib-IX-V Receptor Complex Platelet Platelet activation circulatory and respiratory physiology medicine.drug
Zdroj:	Pathophysiology of Haemostasis and Thrombosis. 29:50-57
ISSN:	1424-8840 1424-8832
DOI:	10.1159/000022460
Popis:	Thrombin formation and blood platelet reactions are intimately linked in haemostasis and in thrombosis. In vivo, procoagulant phospholipids required for the coagulation mechanism are mainly provided by activated platelets, and thrombin is the most potent platelet activator. To study these interactions, an ancient tool of coagulation physiology, the thrombin generation test, was revived and the results obtained were reviewed. The amount of thrombin activity that develops, expressed as the endogenous thrombin potential (the area under the thrombin generation curve), is influenced by the clotting factors (except XII and XIII), the activated protein C system and natural inhibitors on the one hand and by platelet activity on the other. The platelet reactions that we found to be involved are induced by thrombin via glycoprotein (GP) IIb/IIIa activation and by fibrin via interaction with GPIb. von Willebrand factor is crucial in both reactions and therefore an obligatory factor for normal thrombin generation in the presence of platelets. All antithrombotics, be it anticoagulants (e.g. OAC, all heparins or hirudin) or antiplatelet drugs (aspirin, GPIIb/IIIa blockers) diminish thrombin generation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f65b5863d85c2d886795f6da7be8bff https://doi.org/10.1159/000022460 Zobrazit plný text záznamu