Controlled release nitroglycerin capsules

Autor:	J.K. Lalla, Himanshu R. Bhatt, K.K. Dattani, M.L. Gurnasinghani
Rok vydání:	1989
Předmět:	Active ingredient food.ingredient Chromatography Chemistry Stereochemistry Pharmaceutical Science Gelatin Controlled release Dosage form Bioavailability food Membrane Pharmacokinetics In vivo
Zdroj:	Journal of Controlled Release. 9:43-55
ISSN:	0168-3659
DOI:	10.1016/0168-3659(89)90032-1
Popis:	Formulation and evaluation of controlled release nitroglycerin capsules are being reported. The formulation aspects include evaluation of polymer membranes for drug diffusion, coating of sugar beads with drug followed by rate-controlling membrane, and encapsulation in size 00 hard gelatin capsules. The coated beads have been evaluated for surface topography, changes in dimensions and in vitro drug release. The dosage form has also been investigated in vivo in human volunteers using pulse plethysmography. The capsules were found to give controlled release of nitroglycerin during 7 hours. Accelerated stability studies on the capsules during 3 months indicated that the formulation lost only 4.7% of the drug at 50° C and 81 % RH and did not show significant alteration in the dissolution pattern.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f62cc62b98b97acf0737ea3b9d4fbf3 https://doi.org/10.1016/0168-3659(89)90032-1 Zobrazit plný text záznamu