Hepatic and Intestinal Trematodes
| Autor: | E.J. Love, M.J. Miller, W. A. Sodeman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Paragonimus westermani
medicine.medical_specialty Amoscanate Zoology Biology Liver fluke Prepared fish biology.organism_classification Gastroenterology Praziquantel chemistry.chemical_compound chemistry Internal medicine parasitic diseases Opisthorchis medicine Fasciola hepatica Helminths medicine.drug |
| DOI: | 10.1201/9781003068273-24 |
| Popis: | Intestinal trematodes, in spite of complex life cycles, retain a simplicity in transmission to man. They often exploit a niche in the food chain which is deeply embedded in cultural traditions; thus, interruption by simple avoidance becomes a practical impossibility. Infection with liver flukes occurs as a result of inadvertent and/or concomitant ingestion of metacercariae in raw or inadequately prepared fish, vegetable, or insects (ants). The advent of new drugs brings with them a treatment revolution in the approach to liver flukes. Most attention has been directed towards two drugs, praziquantel and amoscanate. Praziquantel is an isoquinoline-pyrazino derivative which has proven to be highly effective against many cestodes infecting man and also effective against selected trematodes. Among the trematodes, praziquantel is highly effective against schistosomes, Paragonimus westermani, C. sinensis and Opisthorchis orvenium. In a single case of Fasciola hepatica, praziquantel has proven ineffective. |
| Databáze: | OpenAIRE |
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