Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure
| Autor: | Jun-Hui Zhang, Sheng-Ming Xie, Xue-Xian Chen, Yun Lyu, Li-Ming Yuan, Li Li, Shi-Guo Fu, Bo Peng, Yan-Xia Li, Ai-Hong Duan |
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| Rok vydání: | 2019 |
| Předmět: |
Ketoprofen
Chromatography Chemistry 02 engineering and technology General Chemistry Mesoporous silica 010402 general chemistry 021001 nanoscience & nanotechnology Chiral stationary phase 01 natural sciences High-performance liquid chromatography 0104 chemical sciences High pressure medicine Enantiomer 0210 nano-technology Retention time medicine.drug |
| Zdroj: | Chemical Research in Chinese Universities. 35:978-982 |
| ISSN: | 2210-3171 1005-9040 |
| DOI: | 10.1007/s40242-019-9162-x |
| Popis: | Highly-ordered inorganic chiral mesoporous silica(HOCMS) has attracted substantial interest in recent decades. High performance liquid chromatography(HPLC) is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS. The column was fabricated by conventional high pressure slurry packing. Eighteen racemates, including alcohols, ketones, amines, aldehydes and organic acids, were resolved on the column. Good chiral separations of hydrobenzoin, metoprolol, propranolol hydrochloride, 4-methyl-2-pentanol, omeprazole, 2,2′-furoin and ketoprofen were obtained. The relative standard devi-ations for five replicate separations of racemates were 0.1%–0.16% for retention time and 1.73%–2.64% for peak areas. The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC. |
| Databáze: | OpenAIRE |
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