Cointegrate formation during mobilization of nonconjugative plasmids by pAP42 plasmid for genetic transfer

Autor:	O. B. Gigani, R. G. Khamidullina, A. P. Pekhov
Rok vydání:	1984
Předmět:	Vitamin Cointegrate Chemistry Enterocyte Genetic transfer Crypt RNA General Medicine digestive system Molecular biology General Biochemistry Genetics and Molecular Biology Small intestine chemistry.chemical_compound Plasmid medicine.anatomical_structure medicine
Zdroj:	Bulletin of Experimental Biology and Medicine. 97:108-111
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00830259
Popis:	The excess of vitamin A, orally administered to young albino male rats (during 8 days, per os, in total dose of 400000 ME per rat) induced a considerable decrease in the number of mitoses in the small intestine crypt glands of both its distal and proximal parts. This treatment also led to changes in the intestine mucosa morphology (decrease of the crypt depth and number of epithelial cells, lining crypts) and to the loss of the RNA content gradient along the villus. It is concluded, that in rats the small intestine mucosa is an organ-target for vitamin A, and its excess induce the inhibition of enterocyte proliferation and impairment of their differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f37d94beb0b77a7ca7933151fa7f92a https://doi.org/10.1007/bf00830259 Zobrazit plný text záznamu Full text from SpringerLink