Neuroendocrine Function and Response to Stress in Mice with Complete Disruption of Glucagon-Like Peptide-1 Receptor Signaling1
| Autor: | Louise A. Scrocchi, Franco J. Vaccarino, Sylvia L. Asa, Jennifer L. Shin, Neil J. MacLusky, Julie Kim, Daniel J. Drucker, Sonya Cook |
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| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty digestive oral and skin physiology Biology chemistry.chemical_compound Endocrinology chemistry Vasopressin secretion Corticosterone Hypothalamus Internal medicine medicine Glucose homeostasis Signal transduction Receptor hormones hormone substitutes and hormone antagonists Testosterone Hormone |
| Zdroj: | Endocrinology. 141:752-762 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.141.2.7326 |
| Popis: | Glucagon-like peptide-1 (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system, where GLP-1 has been implicated in the neuroendocrine control of hypothalamic-pituitary function, food intake, and the response to stress. The finding that intracerebroventricular GLP-1 stimulates LH, TSH, corticosterone, and vasopressin secretion in rats prompted us to assess the neuroendocrine consequences of disrupting GLP-1 signaling in mice in vivo. Male GLP-1 receptor knockout (GLP-1R−/−) mice exhibit reduced gonadal weights, and females exhibit a slight delay in the onset of puberty; however, male and female GLP-1R−/− animals reproduce successfully and respond appropriately to fluid restriction. Although adrenal weights are reduced in GLP-1R−/− mice, hypothalamic CRH gene expression and circulating levels of corticosterone, thyroid hormone, testosterone, estradiol, and progesterone are normal in the absence of GLP-1R−/− signaling. Intriguingly, GLP-1R−/− mice exhibit paradoxic... |
| Databáze: | OpenAIRE |
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