Impact of sex on the incidence of atrial fibrillation in the community setting: a systematic review and meta-analysis
| Autor: | O Ali, L Sowah Quarshie, M Ali, V Vassiliou |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehac544.529 |
| Popis: | Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with significant morbidity and mortality. By 2060, it is estimated that 18 million adults over 55 years will have AF in the European Union, and significant healthcare costs are projected to accompany this substantial increase in prevalence. Sex plays a major role in its pathogenesis, but conflicting results have been reported on whether the risk of new-onset AF differs between men and women. Purpose Undertake a systematic review and meta-analysis of epidemiological studies comparing incidence of new-onset AF between men and women in the community setting. Methods We searched PubMed Medline and Ovid Embase for longitudinal studies from their inception to March 2021. We selected studies if they presented sex-specific incidence estimates of new-onset AF for participants without a prior history of AF. We assessed the risk of bias from methodological quality using the Newcastle Ottawa Scale (NOS). We pooled data using a random-effects model with inverse-variance weighting approach, and carried out subgroup analyses to explore heterogeneity based on age and sampling population. Risk ratio (RR) and 95% confidence interval (CI) were generated to compare the incidence of new-onset AF between men and women. Results A total of 54 prospective cohort studies met the inclusion criteria and were systematically reviewed. Of these, 45 with data on a total of 10,530,623 participants (40% women) were included in the meta-analysis. Pooled analysis demonstrated that men had a statistically significant higher risk of developing new-onset AF than women (RR 1.53; 95% CI 1.42–1.64; p Conclusion This systematic review unequivocally demonstrates that men have a higher risk of new-onset AF than women in the general population. Future research could address the usefulness of screening programmes and provide more empirical evidence for the elderly. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Wolfson Foundation |
| Databáze: | OpenAIRE |
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