String Analysis to identify the Activity of Gyrinops versteegii derived Lauric Acid against Breast Cancer

Autor:	Nova Eka Margiyanti, Anggia Noor Ramadhani, Lisna Hidayati, Nur Fathurahman Ridwan, Tri Rini Nuringtyas, Taufik Adhi Prasetya Wardana
Rok vydání:	2021
Předmět:	Traditional medicine String analysis Gyrinops versteegii Bioengineering Biology medicine.disease Applied Microbiology and Biotechnology Lauric acid chemistry.chemical_compound Breast cancer chemistry medicine lipids (amino acids peptides and proteins) Biotechnology
Zdroj:	Research Journal of Biotechnology. 16:136-140
ISSN:	2278-4535 0973-6263
DOI:	10.25303/167rjbt13621
Popis:	Understanding the interactions between cellular proteins and compounds from agarwood (Gyrinops versteegii) could lead to effective approaches for the diagnosis and treatment of breast cancer. In this study, we aimed to identify the interaction between lauric acid, a compound derived from agarwood (G. versteegii) and its target proteins using String database analysis. String analysis showed that lauric acid affects cellular proliferation through interactions with the Androgen Receptor (AR) and binds to Aldo-Keto Reductase (AKR1C3). Lauric acid also interacted with mitogen-activated protein kinase 1 (MAPK1) and other proteins such as matrix metalloprotein (MMP2), chemokine (CXCL8), B-cell lymphoma protein (BCL2). Retinoid Acid Receptor (RARG) and Androgen Receptor (AR) sub network are bridging system of regulation in breast cancer molecular process. These results show that lauric acid may interact with many proteins by AR sub network to increase apoptosis and reduce cancer cell proliferation. These results show that lauric acid may interact with many proteins to increase apoptosis and reduce cancer cell proliferation.
Databáze:	OpenAIRE
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