15 Mild Cognitive Impairment in Parkinson’s disease
| Autor: | E. Sinforiani, C. Pasotti, C. Pacchetti, Brigida Minafra, I. Bertaina, R. Zangaglia |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty education.field_of_study Parkinson's disease Movement disorders Neurology medicine.diagnostic_test Population medicine.disease behavioral disciplines and activities mental disorders medicine Physical therapy Dementia Memory impairment Neurology (clinical) Neuropsychological assessment medicine.symptom Age of onset Psychology education |
| Zdroj: | Basal Ganglia. 2:261 |
| ISSN: | 2210-5336 |
| DOI: | 10.1016/j.baga.2012.04.016 |
| Popis: | Mild Cognitive Impairment (MCI), is an intermediate stage between normal cognitive function and dementia, is common in Parkinson disease (PD) and its presence might be a risk factor for progression to dementia. The prevalence and profiles of PD-MCI are variable. The aim of this study is to evaluate the relationship between types of PD-MCI and clinical variables of disease in PD patients. Methods We enrolled 300 PD patients consecutively referring to the surgery of Parkinson’s disease and movement disorders of IRCCS “National Institute of Neurology C. Mondino” Foundation of Pavia, Italy from March 2009 to December 2010 and underwent neuropsychological assessment. Of these 100 are PD without cognitive impairment, 145 PD-MCI and 55 PD whit dementia. Patients without cognitive impairment and patients with dementia are excluded. PD-MCI are included. Subjects were classified as having MCI if their age and education corrected z score on one or more cognitive domains was at least 1.5 standard deviations below the mean of normative data. Results In our population the most frequent is MCI non amnesic single domain (naMCI-SD): with logical-executive deficit (43% ), and with visuo-spatial deficit (25 %). The second most frequent MCI is non amnesic multiple domain (naMCI-MD19%). The MCI amnesic single domain (aMCI-SD) in 6% and multiple domain (aMCI-MD) in 7% of patients. The five groups are the same age, education, age of onset and disease severity (UPDRS and HY). The significant differences are a longer disease’s duration in aMCI-MD respect to naMCI-SD, meaning the parallelism between motor and cognitive worsening. Besides in this group hallucinations, anamnestic RBD and confusional episodes are most frequent. Conclusions Our study naMCI-SD is most frequent (LE > VSP) while memory impairment may emerge later. The aMCI-MD in fact, is most frequent associated whit hallucinations, RBD, confusional episodes; could be a prelude to dementia. |
| Databáze: | OpenAIRE |
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