Programmable on-chip DNA compartments as artificial cells
| Autor: | Alexandra M. Tayar, Eyal Karzbrun, Roy Bar-Ziv, Vincent Noireaux |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Science. 345:829-832 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Toward an “artificial cell” on a chip Cell-free systems that reconstitute biochemical pathways have been critical for unraveling the inner workings of the cell. Karzbrun et al. created a highly miniaturized cell-free system on a silicon chip. A series of tiny linked compartments were fabricated on the chip, in which DNA-driven reactions occurred, with materials flowing into and diffusing between the compartments. The system recreated oscillating protein expression patterns and protein gradients, and provides a stepping stone to creating “artificial cells” on a chip. Science , this issue p. 829 |
| Databáze: | OpenAIRE |
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