| Autor: | Leroy B. Townsend, Jack J. Fox, Daniel V. Santi, Petrie Rainey, John A. Secrist, Roland K. Robins, Patricia A. Nolan |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Leishmania tropica biology Organic Chemistry Pharmaceutical Science RNA Metabolism biology.organism_classification Adenosine Tubercidin chemistry Biochemistry parasitic diseases medicine Molecular Medicine L1210 cells Pharmacology (medical) Nucleotide Inosine Biotechnology medicine.drug |
| Zdroj: | Pharmaceutical Research. :217-220 |
| ISSN: | 0724-8741 |
| Popis: | Several criteria were used to select a number of inosine analogs as potential growth inhibitors of the protozoan parasite Leishmania tropica. Of nine compounds tested, seven showed a high degree of selective toxicity towards L. tropica promastigotes as compared to mouse L1210 cells; these include analogs of formycin B, 7-substituted analogs of 7-deazainosine and analogs of inosine in which the sugar moiety has been modified to confer metabolic stability. The metabolism of 7-deazainosine in L. tropica promastigotes was shown to involve conversion to cytotoxic adenosine nucleotide analogs (tubercidin derivatives) that become incorporated into RNA. The results suggest several new classes of compounds which have potential as anti-leishmanial agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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