Factors controlling stem cell recirculation. III. Effect of the thymus on the migration and differentiation of hemopoietic stem cells

Autor:	Khaitov Rakhim M, Petrov Rem, Gulak Lv, NV Aleinikova
Rok vydání:	1977
Předmět:	Pathology medicine.medical_specialty Cellular differentiation medicine.medical_treatment Immunology Cell Biology Hematology Biology Biochemistry Cell biology Endothelial stem cell Transplantation Thymectomy Haematopoiesis medicine.anatomical_structure medicine Bone marrow Stem cell Adult stem cell
Zdroj:	Blood. 49:865-872
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v49.6.865.865
Popis:	Experiments were carried out to investigate the effect of thymectomy on the migration and differentiation of hemopoietic stem cells released from shielded parts of bone marrow after irradiation of mice with lethal doses of x-rays. In 2–3 wk after thymectomy, the rate of migration declined and the differentiation of stem cells into granulocytic colonies was inhibited. Transplantation of syngeneic thymus or lymph node cells into thymectomized mice enhanced the migration of stem cells from the bone marrow and restored the usual pathways of their differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f043da30c77507fc97ac71cf860c01a https://doi.org/10.1182/blood.v49.6.865.865 Zobrazit plný text záznamu