The results of 25 years of cytogenetic investigation of survivors who were exposed to different doses of irradiation during the chernobyl accident

Autor: N. E. Dubochkina, V. Yu. Nugis, Golub Ev, I. Galstyan, Sevan'kaev Av, Khvostunov Ik, M G Kozlova, N. M. Nadejina
Rok vydání: 2011
Předmět:
Zdroj: Biophysics. 56:537-545
ISSN: 1555-6654
0006-3509
DOI: 10.1134/s0006350911030195
Popis: Using routine methods over 25 years, changes in the registered levels of chromosomal aberrations were studied in the peripheral blood lymphocyte cultures of 74 patients who were irradiated as a result of the Chernobyl accident. The initial dosage estimations by mean dicentric frequency varied from 0.2 to 9.8 Gy. Generally, a double exponential type model was most adequate for the quantitative description of the elimination of cytogenetic indexes associated with different types of unstable chromosomal aberrations. Great individual variability of the elimination rate of chromosomal aberrations and its dependency on the value of the originally estimated dosage were found during the first period. A computer method for retrospective dos-age estimation was developed based on this data. The method is based on analysis of cell distributions in accordance with the number of dicentrics and, as a whole, unstable chromosomal aberrations contained in them. In addition, the dynamics of the translocation frequencies in the peripheral blood lymphocyte cultures of a number of patients from this contingent were investigated, beginning at 10 years after the irradiation using the FISH method of chromosome staining.
Databáze: OpenAIRE
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