Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines

Autor:	Francine Agbossou-Niedercorn, Isabelle Suisse, Anna M. Maj, Christophe Hardouin
Rok vydání:	2013
Předmět:	Carbon atom chemistry Organic Chemistry Drug Discovery Asymmetric hydrogenation chemistry.chemical_element Organic chemistry Iridium Biochemistry Catalysis
Zdroj:	Tetrahedron. 69:9322-9328
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.07.090
Popis:	The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4eef0b859715d599e65ecb634ad984a3 https://doi.org/10.1016/j.tet.2013.07.090 Zobrazit plný text záznamu Full Text from ScienceDirect