Secondary haemophagocytic lymphohistiocytosis in a child with brucellosis

Autor:	E P Rhaj Kumar, Varsha Kolachena, Ajay Mohan Varahala, Sravanthi Veldandi, G G Udaya Rani Rani, Ranjeet Malava, Raviteja Moturi, Aparna Alladi, Divya Nalamalapu, Santosh Avinash Boppidi
Rok vydání:	2020
Předmět:	Pediatrics medicine.medical_specialty business.industry medicine Brucellosis medicine.disease business
Zdroj:	International Journal of Contemporary Pediatrics. 7:1645
ISSN:	2349-3291 2349-3283
DOI:	10.18203/2349-3291.ijcp20202634
Popis:	Human brucellosis is a zoonotic infection, mostly caused by B. melitensis and usually presents as an acute febrile illness. Once considered rare in children, it is now recognized that brucellosis can affect persons of all ages, especially in areas where B. melitensis is the predominant species. Complications may affect any organ system. On the other hand Secondary Hemophagocytic lymphohistiocytosis (SHLH) can occur due to systemic infections, immunodeficiency, and underlying malignancies. (SHLH) is histologically characterized by excessive proliferation and activation of histiocytes or macrophages. Brucellosis associated with SHLH should be suspected whenever there is a prolonged fever along with hepatosplenomegaly and pancytopenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4eeb39f5c1e585d34ee8670a5954bcf1 https://doi.org/10.18203/2349-3291.ijcp20202634 Zobrazit plný text záznamu