Gelatin/glycerol coating to preserve mechanically compliant nanowire electrodes from damage during brain implantation
| Autor: | Lina Gällentoft, Jens Schouenborg, Dmitry Suyatin, Nils Danielsen, Christelle N. Prinz, Jolanda A. Witteveen |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
food.ingredient Process Chemistry and Technology Nanowire Nanotechnology engineering.material Gelatin Surfaces Coatings and Films Electronic Optical and Magnetic Materials Glial scar Brain implant food Coating Electrode Materials Chemistry engineering Nanobiotechnology Implant Electrical and Electronic Engineering Instrumentation |
| Zdroj: | Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena. 28:C6K13-C6K16 |
| ISSN: | 2166-2754 2166-2746 |
| DOI: | 10.1116/1.3498764 |
| Popis: | Chronically implanted neural implants are of clinical importance. However, currently used electrodes have several drawbacks. Some weeks after implantation in the brain, a glial scar forms around the electrode, causing decreased electrode functionality. Nanostructures, and in particular nanowires, are good candidates to overcome these drawbacks and reduce glial scar formation. Using a mechanically compliant substrate with protruding nanowires could further decrease the glial scar formation by reducing the mechanical mismatch between the tissue and the electrode. However, flexible substrates require strengthening upon brain implantation. One solution consists of embedding the implant in a gelatin-based matrix, which is resorbable. In the case where nanostructures are present at the surface of the implant, it is crucial that the embedding matrix also preserves the nanostructures, which can be challenging considering the forces involved during the drying phase of gelatin. Here, the authors show that freestand... |
| Databáze: | OpenAIRE |
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