Antidiabetic effect of Gynura procumbens leaves extracts involve modulation of hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats
| Autor: | Amir Rabu, Pusparanee Hakim, Hui Wen Lee, Halimah Abdullah Sani |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Hexokinase Glycogen biology Chemistry Pharmaceutical Science Gynura procumbens Endogeny Plant Science Carbohydrate metabolism biology.organism_classification Streptozotocin chemistry.chemical_compound Complementary and alternative medicine Biochemistry Drug Discovery medicine Glycolysis Phosphofructokinase medicine.drug |
| Zdroj: | Journal of Medicinal Plants Research. 6 |
| ISSN: | 1996-0875 |
| DOI: | 10.5897/jmpr11.1466 |
| Popis: | Gynura procumbens is an annual evergreen shrub found in Southeast Asia, especially Malaysia, Thailand and Indonesia, which is of considerable medicinal value. The present study aims to investigate the antidiabetic properties of G. procumbens leaves aqueous and ethanolic extracts and its possible underlying antihyperglycemic mechanisms of action involving liver carbohydrate metabolism in streptozotocin-induced diabetic rats. Experimental diabetes was induced via single intravenous injection of streptozotocin (55 mg/kg of body weight). G. procumbens leaves aqueous and ethanolic extracts were administered orally at 3 different doses (50, 100 and 150 mg/kg of body weight) for 42 consecutive days. Administration of G. procumbens leaves aqueous and ethanolic extracts significantly (P |
| Databáze: | OpenAIRE |
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