Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitors
| Autor: | Schow Steven R, Suresh S. Kerwar, Michael M. Wick, Robert E. Babine, Randal A. Byrn, Bernard Dean Johnson, Michael R. Jirousek, Parimal R. Desai, Richard C. Hastings, Nan Zhang |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
biology Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science medicine.disease_cause Biochemistry chemistry.chemical_compound Enzyme HIV-1 protease Enzyme inhibitor Drug Discovery biology.protein medicine Molecular Medicine Molecular Biology Lead compound |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1589-1594 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80023-2 |
| Popis: | Lead compound 1, obtained from a previously reported structure-assisted design approach, was optimized to 17 using a traditional medicinal chemistry approach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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