Epigenetics and pathogensis: A newflanged review
| Autor: | Surinder Sachdeva, Avineet Kaur, Shailja Chatterjee, Kanwar Shabaz, Harnoor Singh Sandhu, Raman Chopra |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Periodontitis business.industry 030206 dentistry Periodontium Disease medicine.disease Phenotype 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genotype-phenotype distinction Immunology medicine Tooth loss Anaerobic bacteria Epigenetics medicine.symptom business |
| Zdroj: | IP International Journal of Periodontology and Implantology. 5:134-138 |
| ISSN: | 2457-0087 2581-9836 |
| DOI: | 10.18231/j.ijpi.2020.031 |
| Popis: | Genetics and epigenetics is the process of gene expression or suppression through polymorphism, demethylation, and deacetylation. Although Periodontal diseases are bacterial infections predominantly gram negative anaerobic bacteria that colonize the sub gingivaly in return triggering an inflammatory response which affect the periodontium; whereas periodontitis is a periodontal disease which destroys the tissue and bone that surrounds the tooth. In adults periodontitis is at helm of tooth loss. Pathogenic microrgansims are considered as the primary aetiological factor, but the disease progression is also influenced by Genotype and Phenotype of various individuals. Phenotypic factors such as race, diabetes, gender, education, smoking etc. have sweeping effects on the epigenetic changes and impel susceptibility to disease. Epigenetic modifications expression occur in response to environmental changes. Keywords: Epigentics, Genotype, Periodontitis. |
| Databáze: | OpenAIRE |
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