Infección por el VIH (I)
| Autor: | F. Lozano de León-Naranjo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Premature aging
business.industry Human immunodeficiency virus (HIV) General Medicine medicine.disease medicine.disease_cause Virology Antiretroviral therapy Immune system Acquired immunodeficiency syndrome (AIDS) Immunology Antiretroviral treatment Medicine business Hiv transmission Immune activation |
| Zdroj: | Medicine - Programa de Formación Médica Continuada Acreditado. 11:2893-2901 |
| ISSN: | 0304-5412 |
| DOI: | 10.1016/s0304-5412(14)70712-7 |
| Popis: | The access to antiretroviral treatment has contributed to a global decrease in the number of new HIV infections, although the HIV pandemia continues to be a global challenge. In Spain, HIV transmission is mainly attributed to sexual relations among men. A 46 % of the new diagnoses has made lately. HIV infects CD4+ T lymphocytes, inducing an important reduction of the number of these cells, favoring the opportunistic and neoplastic entities defining AIDS. Likewise, HIV infection induces a persistent immune activation and a chronic inflammatory state, both implicated in the decrease of CD4+ T cells number, premature aging, multiorganic damage and non-AIDS defining neoplasias. The antiretroviral therapy has a limited activity against these immune and inflammatory activation-related diseases. |
| Databáze: | OpenAIRE |
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