Effects of long-term combination chemotherapy on the reticuloendothelial system
| Autor: | L. Domellöf, L. Athlin, L. Berghem |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Cancer Research
Vincristine medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Phagocytosis Cancer Combination chemotherapy Mononuclear phagocyte system medicine.disease Gastroenterology Peripheral blood mononuclear cell Oncology Internal medicine Immunology medicine Platelet business medicine.drug |
| Zdroj: | Cancer. 53:2073-2078 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19840515)53:10<2073::aid-cncr2820531012>3.0.co;2-z |
| Popis: | The phagocytic and metabolic functions of the reticuloendothelial system (RES) were studied in 20 postoperative cancer patients undergoing long-term combination chemotherapy. Each course included vincristine, methyl-CCNU (day 1) and 5-fluorouracil (days 1-5) every sixth week. The RES-test was performed prior to each course, using /sup 125/I-labeled microaggregated human serum albumin. Total leukocytes, mononuclear cells and platelets were monitored before, during and after each treatment. A significant, initial impairment of the catabolic function of the RES was found (2P . 0.006). A similar, nonsignificant trend was observed in the phagocytic function. The normalization may mirror the large metabolic capacity of the RES. This is further demonstrated by the fact that splenectomized (N . 9) and nonsplenectomized patients did not differ. A significant decrease was also found in total leukocytes and mononuclear cells (2P less than 0.001). Combination chemotherapy induced a similar myelosuppression in both groups, but did not further reduce the mobile RES in asplenic individuals. |
| Databáze: | OpenAIRE |
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