Cross-Nucleation between d-Mannitol Polymorphs in Seeded Crystallization

Autor:	Karen J. Jones, Jing Tao, Lian Yu
Rok vydání:	2007
Předmět:	Chemistry Nucleation food and beverages Crystal growth General Chemistry Crystal structure Condensed Matter Physics law.invention Crystallography Polymorphism (materials science) law Melting point General Materials Science Crystallization Supercooling Seed crystal
Zdroj:	Crystal Growth & Design. 7:2410-2414
ISSN:	1528-7505 1528-7483
DOI:	10.1021/cg070387i
Popis:	Seeding the liquid of d-mannitol with its polymorphs (α, β, and δ) revealed several cases of cross-nucleation between polymorphs. Only seeds of the α polymorph (the structure of the intermediate thermodynamic stability and the fastest growth rate) yielded the same polymorph in new growth. Seeds of the δ polymorph yielded the α polymorph in new growth. Seeds of the β polymorph yielded the β polymorph in new growth at small undercoolings (a few degrees below its melting point); at lower temperatures, the α polymorph nucleated on β seeds and its amount in the product increased with decreasing temperature. Seeding with single crystals of the β polymorph (rods elongated along c) showed that the orientation of the seed crystal affected how much the seed polymorph could grow before cross-nucleation occurred. Cross-nucleation makes seeding ineffective for achieving polymorphic selectivity but is sometimes avoidable by choosing suitable crystallization conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ec62453f307f4eb62ebde71a84d2b4d https://doi.org/10.1021/cg070387i Zobrazit plný text záznamu