PERINATAL IRON DEFICIENCY DECREASES CYTOCHROME OXIDASE (CytOx) ACTIVITY IN SPECIFIC REGIONS OF NEONATAL RAT BRAIN † 1721

Autor:	Michael K. Georgieff, Raghavendra Rao, Monica Luciana, Marissa deUngria
Rok vydání:	1997
Předmět:	medicine.medical_specialty business.industry Putamen Dentate gyrus Hippocampus Anatomy Hippocampal formation Amygdala Endocrinology medicine.anatomical_structure Hypothalamus Piriform cortex Internal medicine Pediatrics Perinatology and Child Health Cingulum (brain) Medicine business
Zdroj:	Pediatric Research. 41:289-289
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199704001-01740
Popis:	Brain iron deficiency bodes poorly for cognitive neurodevelopment and is present in newborns following gestations complicated by diabetes mellitus or intrauterine growth retardation. CytOx is an iron-containing enzyme involved in oxidative phosphorylation; its activity reflects neuronal metabolism. Regional CytOx activity has been mapped in the iron-sufficient adult rat brain but not in iron-sufficient or -deficient neonates. We hypothesized that neonatal brain iron deficiency alters regional CytOx activity. Pregnant Sprague-Dawley rats were fed iron-deficient or -sufficient chow from GD 1 until PND 7. CytOx activity in 14 brain nuclei (9 involved in memory pathways) was measured histochemically utilizing diaminobenzidine in frozen 15 μ coronal brain sections located approximately 2 mm posterior to the auditory meatus in 13 iron-deficient and 11 iron-sufficient pups. Quantitation of optical density (OD) was by Image-1. Brain iron concentration was 45% lower(p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ec37dcdf9fe4a9a78648723aeeb4159 https://doi.org/10.1203/00006450-199704001-01740 Zobrazit plný text záznamu