In vitro mitogenic effect of Zn2+ on peripheral blood lymphocytes in patients with cancer
| Autor: | David W. Braun, Robert A. Good, John A. Garofalo, Susanna Cunningham-Rundles |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
inorganic chemicals
Pharmacology business.industry Activator (genetics) education Immunology hemic and immune systems chemical and pharmacologic phenomena medicine.disease In vitro Peripheral blood Lymphoma Epidermoid carcinoma biological sciences Medicine Adenocarcinoma In patient business Head and neck |
| Zdroj: | International Journal of Immunopharmacology. 2:37-40 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(80)90007-7 |
| Popis: | The methodology for evaluating the mitogenic effect of Zn2+ on human PBL was standardized in a microtiter system. In normal subjects the maximal PBL transformation response occurred in 6–7 day cultures at a Zn2+ concentration of 0.1–0.5 mM. Utilizing PHA as a reference cell activator, the in vitro PBL response to Zn2+ was evaluated in a heterogeneous population of patients with adenocarcinoma of the breast, epidermoid carcinoma of the head and neck, and lymphoma. In all cases the PBL responses to Zn2+ were depressed in a fashion similar to PHA. Zn2+ appears to be a sensitive activator of PBL and may prove of value in the in vitro immunologic evaluation of patients with cancer. |
| Databáze: | OpenAIRE |
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