A facile preparation of ammonium [14C]thiocyanate
| Autor: | S. P. Patil, D. B. Kalgutkar, N. Jayachandran, V. K. P. Unny |
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| Rok vydání: | 2005 |
| Předmět: |
Aqueous solution
Thiocyanate Health Toxicology and Mutagenesis Cyanide Potassium Inorganic chemistry Public Health Environmental and Occupational Health chemistry.chemical_element Pollution Analytical Chemistry chemistry.chemical_compound Column chromatography Nuclear Energy and Engineering chemistry Thiourea Yield (chemistry) Radiology Nuclear Medicine and imaging Ammonium Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 266:75-78 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-005-0871-x |
| Popis: | An attractive and simple method has been developed for the preparation of ammonium [14C]thiocyanate from [14C]thiourea which eliminates the necessity of handling highly hazardous potassium [14C] cyanide. [14C]thiourea was isomerized to ammonium [14C]thiocyanate by heating the aqueous solution of thiourea (12%) in a sealed tube at 160 °C for 24 hours. The product formed was purified by silica-gel column chromatography. A radiochemical yield of 92.7% was obtained based on [14C]thiourea. The specific activity of the product obtained was 53.3 mCi/mmol (1.97 GBq/mmol) and the radiochemical purity was greater than 99%. This method has not been reported so far for the production of this labeled compound. |
| Databáze: | OpenAIRE |
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