Value of Serum Sclerostin in Osteopenia and Osteoporosis Associated with Liver Cirrhosis and Post Liver Transplantation
| Autor: | Maha M. Hussein, Safwat W, Manal M. Mohse, Mohamed Abou El-EZZ, Wael A. Yousry |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry medicine.medical_treatment Osteoporosis Parathyroid hormone 030209 endocrinology & metabolism Osteoblast Liver transplantation medicine.disease Osteopenia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure Endocrinology chemistry Internal medicine Medicine Sclerostin 030211 gastroenterology & hepatology Osteodystrophy business |
| Zdroj: | IOSR Journal of Dental and Medical Sciences. 15:59-64 |
| ISSN: | 2279-0853 2279-0861 |
| DOI: | 10.9790/0853-1508065964 |
| Popis: | Background: Osteodystrophy is one of the signs of liver cirrhosis. In general, maintenance of bone over time requires balance between the formation of new bone tissue and breakdown and removal of old bone tissue. This balance is maintained by a variety of hormones. One of them is sclerostin.Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits osteoblastic proliferation and differentiation and promotes osteoblast apoptosis. Aim of the work: Evaluation of serum sclerostin level in relation to osteopenia o serum sclerostine level, calcium phosphorus,parathyroid hormone levels were measured, in addition to Dexa scan. Results: Serum sclerostin level was present in highest concentration in group II (33.99 ± 13.8 ng/ml) compared to group I (15.01 ± 1.87 ng/ml) & group III patients (9.98 ± 1.12 ng/ml).Osteoporosis and osteopenia were significantly most frequent in Child B and C patients (59.4%) compared to Child A (25.1%)and patients post liver transplantation (12.5%).Serum sclerostin level was highest in osteoporotic patients (36.24 ± 11.9 ng/ml), followed by osteopenic patients (30.17± 11.7 ng/ml). Patients with normal Dexa scan had the lowest serum sclerostin level (14.91± 10.7 ng/ml). Conclusion: sclerostin is a good predictor for presence of bone diseases in patients with liver cirrhosis.It has sensitivity of 80.8% at serum level ≥17.7 ng/ml |
| Databáze: | OpenAIRE |
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