| Popis: |
Background Macrophages, within which Leishmania sp. replicate, generate large amounts of reactive oxygen species (ROS) and reactive nitrogen species (RNS) to kill these parasites. Methods The aim of the present study was to assess oxidative, nitrosative stresses, and some immune enzymes in blood of cutaneous leishmaniasis (CL) patients before and after treatment as well as in control individuals. Serum activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidas (GSH-Px) and the levels of reduced glutathione, malondialdehyde (MAD) and nitric oxide (NO) as well as L-arginase, myeloperoxidase (MPO), adenosine deaminase (ADA) have been studied. Results The activities of the L-arginase, MPO and ADA, the levels of MDA and NO are significantly elevated (P < 0.001), while that of SOD, CAT, and GSH-Px, and GSH level were significantly (P < 0.001) reduced in untreated patients compared with the corresponding activities of the treated and control individuals. The treatment ameliorated these agents in comparison to the untreated group but there was still variations between the values of treated and control groups. Conclusion These results suggested that oxidative and nitrusative stress may play an important role in the pathogenesis of untreated cutaneous leishmaniasis |
