Testis transcriptome profiling identified lncRNAs involved in spermatogenic arrest of cattleyak

Autor: Chuanping Yi, Wangsheng Zhao, Hui Luo, Jincheng Zhong, Hongying Wang, Chuanfei Xu, Shixin Wu, TserangDonko Mipam, Xin Cai
Rok vydání: 2021
Předmět:
Zdroj: Functional & Integrative Genomics. 21:665-678
ISSN: 1438-7948
1438-793X
Popis: Cattleyaks are the crossbred offspring between cattle and yaks, exhibiting the prominent adaptability to the harsh environment as yaks and much higher growth performances than yaks around Qinghai-Tibet plateau. Unfortunately, cattleyak cannot be effectively used in yak breeding due to its male infertility resulted from spermatogenic arrest. In this study, we performed RNA sequencing (RNA-seq) and bioinformatics analysis to determine the expression profiles of long noncoding RNA (lncRNA) from cattleyak and yak testis. A total of 604 differentially expressed (DE) lncRNAs (135 upregulated and 469 downregulated) were identified in cattleyak with respect to yak. Through gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, we identified several DE lncRNAs regulating the mitotic cell cycle processes by targeting the genes significantly associated with the mitotic cell cycle checkpoint and DNA damage checkpoint term and also significantly involved in p53 signaling pathway, mismatch repair and homologous recombination pathway (P
Databáze: OpenAIRE
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