Solubility measurement and preparation of nanoparticles of ampicillin using subcritical water precipitation method

Autor: Hadi Share Mohammadi, Maryam Khajenoori, Ali Haghighi Asl
Rok vydání: 2021
Předmět:
Zdroj: Korean Journal of Chemical Engineering. 38:2304-2312
ISSN: 1975-7220
0256-1115
DOI: 10.1007/s11814-021-0891-4
Popis: To improve the bioavailability of ampicillin trihydrate (AMP) as a poorly water-soluble drug, the nanonization of AMP particles was carried out by solvent anti-solvent precipitation for the first time. In this method the subcritical water (SW) and cold water at ambient conditions were utilized as the solvent and anti-solvent, respectively. At first, the solubility of AMP in SW was measured. The solubility of AMP in SW at a constant pressure of 5 MPa and the temperature range from 303.15 to 403.15 K was found to range from 0.380×10−3 to 17.689×10−3 mole fractions. The effects of three independent variables, including SW temperature, polyethylene glycol concentration, and anti-solvent temperature, on the particle size and morphology of the precipitated nanoparticles were studied. The obtained results of analyses confirmed that the AMP particles were nanosized to the smallest mean size of 66.5 nm using an environmentally friendly method without the requirement of organic solvents and related post-processing purification stages.
Databáze: OpenAIRE
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