Behavior, genetics and biochemistry of an allele of the mutant mouse spastic, spalb

Autor:	Regan Lj, Anne Messer, Anna W. Roe, White Wf
Rok vydání:	1987
Předmět:	Genetics medicine.medical_specialty Mutant Central nervous system Biology Spinal cord Cellular and Molecular Neuroscience medicine.anatomical_structure Endocrinology Internal medicine medicine Righting reflex Spasticity Brainstem Allele medicine.symptom Glycine receptor
Zdroj:	Journal of Neurogenetics. 4:253-258
ISSN:	1563-5260 0167-7063
DOI:	10.3109/01677068709102345
Popis:	A new autosomal recessive mutation, characterized by an early defect in righting reflex and stiffened gait, progression to severe spasticity, tremor and rigidity, and death before weaning, appeared spontaneously on the C57BL/6 background. It was shown to be an allele of the mutant spastic spa, and shall be known as spaAlb. Mutant levels of [3H]strychnine binding are less than 10% of control levels in the brainstem and spinal cord. Autoradiographic examination of the distribution of [3H]strychnine binding sites in the mutant confirm a greatly reduced level of binding compared to control in all areas of the spinal cord, brainstem, and midbrain.
Databáze:	OpenAIRE
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