Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy
| Autor: | Swastika Maity, K. Sreedhara Ranganath Pai, Devinder Arora, Madhavan Nampoothiri, Jayesh Mudgal, Manas Kinra |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
chemistry.chemical_classification Combination therapy Chemistry Dietary constituent General Chemical Engineering media_common.quotation_subject General Chemistry Pharmacology Hydroxycinnamic acid Biochemistry Industrial and Manufacturing Engineering Dietary Polyphenol Metformin chemistry.chemical_compound Polyphenol Materials Chemistry medicine Caffeic acid media_common medicine.drug |
| Zdroj: | Chemical Papers. 76:1271-1283 |
| ISSN: | 2585-7290 0366-6352 |
| DOI: | 10.1007/s11696-021-01947-7 |
| Popis: | Increased effectiveness and decreasing toxicity are prime objectives in drug research. Overwhelming evidence suggests the use of appropriate combination therapy for the better efficacy of drugs owing to their synergistic profile. Dietary active constituents play a major role in health outcomes. Therefore, it is possible to increase the effectiveness of the drug by combining contemporary medication with active natural/semi-synthetic constituents. One such dietary constituent, caffeic acid (CA), is a by-product of the shikimate pathway in plants and is a polyphenol of hydroxycinnamic acid class. Extensive research on CA has proposed its efficacy against inflammatory, neurodegenerative, oncologic, and metabolic disorders. The synergistic/additive effects of CA in combination with drugs like caffeine, metformin, pioglitazone, and quercetin have been reported in several experimental models and thus the present review is an attempt to consolidate outcomes of this research. Multi-target-based mechanistic studies will facilitate the development of effective combination regimens of CA. |
| Databáze: | OpenAIRE |
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