Evaluation of Prophylaxis with Norfloxacin and Ceftriaxone versus Ciprofloxacin during the Period of Neutropenia after Haematopoietic Stem Cell Transplantation: Retrospective Analysis of Two Sequencial Cohorts

Autor:	Carlos Alberto Pires Pereira, José Salvador Rodrigues de Oliveira, Janaina Midori Goto, Maria Daniela Bergamasco, Paola Cappellano, Valeria Paes Lima Fernandes
Rok vydání:	2014
Předmět:	medicine.medical_specialty business.industry Aplasia Neutropenia medicine.disease Surgery Transplantation Ciprofloxacin General Energy Internal medicine medicine Ceftriaxone Mucositis business Norfloxacin Febrile neutropenia medicine.drug
Zdroj:	Advances in Infectious Diseases. :77-86
ISSN:	2164-2656 2164-2648
Popis:	Background: The aim of this study was to evaluate the occurrence of febrile neutropenia (FN) during aplasia after haematopoietic stem cell transplantation (HSCT) in patients who received anti-bacterial prophylaxis with norfloxacin/ceftriaxone or ciprofloxacin, between September 2006 and May 2009. Methods: We retrospectively examined all patients undergoing HSCT at S?o Paulo Hospital during the study period. Results: Of the 107 studied patients, 71 (66.3%) were included in the analysis. The exclusion criteria were as follows: occurrence of fever or infection before the transplantation (17), prophylactic use of norfloxacin (6), fever of probable non-infectious aetiology (2), and absence of prophylaxis during the aplasia period (11). Thirty-eight patients received norfloxacin and ceftriaxone as prophylaxis (Group I) and 33 received ciprofloxacin (Group II). The groups were comparable with respect to age, underlying diseases, comorbidities, and status of the underlying disease. Patients in Group II used antibiotics in a significantly higher frequency than those in Group I (66.7% vs 33.8%, p = 0.017), for 30 days before transplantation. The number of previous hospitalisations, length of hospitalisation until transplantation, type of transplant, progenitor cells used, number of CD34 cells infused, type of conditioning, and graft-versus-host disease prophylaxis were similar in both groups. After the transplantation, 28.9% and 39.4% of the patients in Groups I and II, respectively, presented Grade III and IV mucositis (p = 0.448). Neutropenia of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4e7d8f1a98a7cd6b1729c0e64801a39b https://doi.org/10.4236/aid.2014.42013 Zobrazit plný text záznamu