Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity

Autor:	Nikolai S. Li-Zhulanov, Dina V. Korchagina, Tatyana G. Tolstikova, Konstantin P. Volcho, Yurii V. Gatilov, Nariman F. Salakhutdinov, Alla Pavlova
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Organic Chemistry Analgesic Sulfuric acid Diclofenac Sodium Benzyl cyanide 010402 general chemistry medicine.disease_cause 01 natural sciences Ritter reaction 0104 chemical sciences chemistry.chemical_compound In vivo medicine Organic chemistry Hot plate test Irritation
Zdroj:	Chemistry of Heterocyclic Compounds. 56:936-941
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-020-02753-x
Popis:	The Ritter reaction between monoterpenoid (–)-isopulegol and nitriles in the presence of concentrated sulfuric acid or trifluoromethanesulfonic acid yielded a series of chiral 1,3-oxazine derivatives. When studying the analgesic activity of the synthesized compounds in vivo, it was found that 1,3-oxazine synthesized by the reaction of (–)-isopulegol with benzyl cyanide increases the time of latency of the animal in the hot plate test of thermal pain irritation, not inferior in effectiveness to the comparison drug diclofenac sodium.
Databáze:	OpenAIRE
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