Poly(ethylene glycol) modified Mn2+ complexes as contrast agents with a prolonged observation window in rat MRA
| Autor: | Hou-Bing Zhang, Li Yang, Jiang Zhu, Bingbing Lin, Hua Ai, Danyang Li, Zhuzhong Chen, Xiao-Ming Zhang, Changqiang Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Poly ethylene glycol Stereochemistry General Chemical Engineering Alkyne 02 engineering and technology General Chemistry Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Pyrrolidine 0104 chemical sciences chemistry.chemical_compound chemistry Time windows Pyridine PEG ratio Polymer chemistry Click chemistry 0210 nano-technology |
| Zdroj: | RSC Advances. 7:54603-54609 |
| ISSN: | 2046-2069 |
| Popis: | A novel rigid Mn2+ complex (MnL) with pyridine and pyrrolidine rings was designed and synthesized. The complex was further modified with alkyne, and conjugated to azide-terminated PEG by click chemistry. PEGylated MnL shows considerably higher relaxivity (MnL-PEG2k-MnL: r1 = 6.38 mmol−1 s−1; MnL-PEG4.6k-MnL: r1 = 5.63 mmol−1 s−1) and much longer blood circulation time than free Mn2+ complexes (MnL: r1 = 3.73 mmol−1 s−1), providing a prolonged time window to acquire longitudinal images for rat contrast enhanced magnetic resonance angiography. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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