| Autor: |
Solofo Razafimahatratra, Thomas Guieysse, François-Xavier Lejeune, Marion Houot, Takfarinas Medani, Gérard Dreyfus, André Klarsfeld, Nicolas Villain, Filipa Raposo Pereira, Valentina La Corte, Nathalie George, Dimitrios Pantazis, Katia Andrade |
| Rok vydání: |
2022 |
| Popis: |
Anosognosia, or the lack of awareness of one’s own impairment, is frequent for memory deficits in patients with Alzheimer’s disease (AD). Although often related to frontal dysfunctions, the neural mechanisms of anosognosia remain largely unknown. We hypothesized that anosognosia in AD may result from a failure in the error-monitoring system, thus preventing patients from being aware of and learning from their own errors. We therefore investigated the event-related potentials evoked by erroneous responses during a memory task in two groups of amyloid positive individuals who had only subjective memory complaints at study entry: 1) those who progressed to AD; and 2) those who remained cognitively normal after five years of follow-up. Our findings revealed direct evidence of a failure in the error-monitoring system at early stages of AD, suggesting that it may be the critical neural substrate of anosognosia in this neurodegenerative disorder. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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