Associations between the incidence of antiphosphatidylserine and antiphosphatidylethanolamine antibodies and clinical manifestations of systemic lupus erythematosus
Autor: | Filip Butkiewicz, Michał Borowiak, Jan Iżbicki, Katarzyna Fischer, Jacek Fliciński, Marek Kubiś, Michał Szelepajło, Hubert Lopiński, Michał Kaszuba, Michał Brzeziński |
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Rok vydání: | 2014 |
Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry Incidence (epidemiology) Autoantibody Antiphosphatidylethanolamine antibodies medicine.disease Gastroenterology immune system diseases Antiphospholipid syndrome Internal medicine Erythrocyte sedimentation rate Internal Medicine medicine biology.protein In patient Myocardial infarction Antibody skin and connective tissue diseases business |
Zdroj: | Polish Archives of Internal Medicine. 124:573-578 |
ISSN: | 1897-9483 |
Popis: | INTRODUCTION Antiphosphatidylethanolamine antibodies (aPE) and antiphosphatidylserine antibodies (aPS) belong to a group of antiphospholipid antibodies (aPL) that occur in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). OBJECTIVES The aim of this study was to examine associations between the elevated serum concentration of aPE/aPS, the clinical manifestations of SLE, and the presence of other autoantibodies. PATIENTS AND METHODS The study group included 71 patients with SLE. The control group comprised 36 healthy volunteers. In both groups, serum aPS and aPE concentrations were measured with enzyme‑linked immunosorbent assays. Clinical data, including clinical manifestations and the laboratory markers of SLE, were obtained from medical records. RESULTS The study revealed a higher prevalence of aPE in patients with SLE than in controls (54.93% vs. 5.56%). aPS were observed in the study group less frequently compared with aPE (12.68% vs. 54.93%) and were absent in controls. Anticardiolipin antibodies and APS were found to be associated with the presence of aPS. Thrombocytopenia, Raynaud phenomenon, and myocardial infarction were observed more frequently among aPS‑positive patients. The presence of aPE was also associated with the occurrence of mucosal ulcers in the mouth cavity. A positive correlation between aPS and erythrocyte sedimentation rate (ESR) was also observed. The serum concentration of aPE inversely correlated with red blood cell count and positively with ESR. CONCLUSIONS The presence of aPS in patients with SLE is associated with thrombocytopenia, Raynaud phenomenon, and cardiac complications. |
Databáze: | OpenAIRE |
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