Concentration of antibiotics in renal interstitial fluid, soft tissue interstitial fluid, urine and serum

Autor:	L. Scharfenberger, H. U. Eickenberg, N. G. Waterman
Rok vydání:	1976
Předmět:	Microbiology (medical) Pathology medicine.medical_specialty medicine.drug_class Tetracycline Chemistry Antibiotics Soft tissue General Medicine Urine Serum concentration Infectious Diseases Pharmacokinetics Interstitial fluid Ampicillin medicine medicine.drug
Zdroj:	Infection. 4:S97-S104
ISSN:	1439-0973 0300-8126
DOI:	10.1007/bf01674477
Popis:	Utilizing multiperforated capsules implanted in tissue, the concentrations of cephalotin, ampicillin, and tetracycline in soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were measured simultaneously and compared with concentrations found in serum and urine in dogs. Antibiotic concentration in RIF was less than urinary levels but exceeded serum concentrations. A direct time-concentration relationship of these three structurally unrelated antibiotics in serum and renal interstitial fluid was found. This model helps illuminate the basic pharmacokinetics of antibiotic in the renal interstitium where pyelonephritis occurs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4e75cc486c6a43fa5019709e7bf0409e https://doi.org/10.1007/bf01674477 Zobrazit plný text záznamu Full text from SpringerLink