Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer
| Autor: | Cyrus M. Ghajar, Sarah B Crist |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tumor microenvironment Histology medicine.drug_class business.industry Cell Biology medicine.disease Lapatinib Tyrosine-kinase inhibitor Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Cell culture 030220 oncology & carcinogenesis Cancer research medicine DNA microarray skin and connective tissue diseases business Receptor neoplasms medicine.drug |
| Zdroj: | Cell Systems. 6:268-270 |
| ISSN: | 2405-4712 |
| DOI: | 10.1016/j.cels.2018.03.005 |
| Popis: | Summary Watson et al. use microenvironment microarrays to assess how extrinsic signals within the tumor microenvironment influence HER2 ++ breast cancer resistance to the HER2-targeted tyrosine kinase inhibitor lapatinib. |
| Databáze: | OpenAIRE |
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