Association of polymorphisms of platelet membrane integrins αIIbβ3 (HPA‐1b/PlA2) and α2β1 (α2807TT) with premature myocardial infarction
| Autor: | Winfried März, Bernhard O. Boehm, Rainer B. Zotz, C. Müller, Ruediger E. Scharf, Bernhard R. Winkelmann |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
biology business.industry Hematology medicine.disease Platelet membrane glycoprotein Human platelet antigen Coronary artery disease Internal medicine Diabetes mellitus medicine biology.protein Cardiology Platelet Myocardial infarction Age of onset business Coronary atherosclerosis |
| Zdroj: | Journal of Thrombosis and Haemostasis. 3:1522-1529 |
| ISSN: | 1538-7836 |
| DOI: | 10.1111/j.1538-7836.2005.01432.x |
| Popis: | Summary. Conflicting results of an association of the human platelet antigen 1b (HPA-1b/PlA2), localized on the β-subunit of the integrin αIIbβ3, and the α2807TT genotype of the integrin α2β1 with coronary atherosclerosis and myocardial infarction have been reported. Both platelet receptor polymorphisms were genotyped in 3261 patients who had undergone coronary angiography, including 1175 survivors of a myocardial infarction, 1211 individuals with coronary artery disease but no history of myocardial infarction, and 571 control patients without angiographic coronary artery disease, and in 793 blood donors. In a case–control design, the prevalence of HPA-1b and α2807TT genotypes did not differ significantly between the patient groups with coronary artery disease or myocardial infarction and patient controls or blood donors. By contrast, using a multivariate case-only design, it was found that the median age of onset of myocardial infarction was 5.2 years earlier (P = 0.006) in carriers of the HPA-1b allele and 6.3 years earlier (P = 0.006) in carriers of the α2807TT genotype in the 264 survivors of myocardial infarction of recent onset with one- or two-vessel coronary artery disease. A significant interaction with the conventional risk factors hypercholesterolemia, smoking, diabetes, hypertension, and hyperfibrinogenemia was excluded. Human platelet antigen 1b and α2807TT are associated with premature myocardial infarction but not with coronary artery disease, suggesting a role of distinct integrin genotypes for increased platelet thrombogenicity. This association requires confirmation in follow-up studies. |
| Databáze: | OpenAIRE |
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