Impact of Genomics on Personalization of Breast Cancer Care
| Autor: | F. Scott Heinemann, Alice Police, Erin Lin, Mandy Liu, Sherry Liang, Ying Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry Breast imaging medicine.medical_treatment Disease medicine.disease Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Quality of life 030220 oncology & carcinogenesis Internal medicine Hormonal therapy Medicine skin and connective tissue diseases business Breast reconstruction Mastectomy |
| Zdroj: | Genomics-Driven Healthcare ISBN: 9789811075056 |
| Popis: | Over the past 50 years, progress on multiple fronts has dramatically altered the nature of the disease known as breast cancer. The initiation of randomized prospective clinical trials in 1959, a novel concept at the time, by the National Surgical Adjuvant Breast and Bowel Project (NSABP) under the guidance of Bernard Fisher established a scientific philosophy as the guiding force in breast cancer treatment. Since 1975, multiple innovations have increased the therapeutic options and improved the outcomes available to women with breast cancer. Increased awareness of breast cancer, improvements in breast imaging, and the development of screening programs have made early diagnosis commonplace. The de-radicalization of surgical techniques used to obtain local control and the application of plastic surgical techniques for breast reconstruction have dramatically reduced the morbidity associated with mastectomy and axillary dissection. The development of pharmacologic hormonal therapy, more effective cytotoxic chemotherapy, and targeted HER2 therapy has improved survival for women with the most common types of breast cancer as well as less common but highly aggressive cancers. The development of predictive assays for response to chemotherapy has spared many patients from unnecessary toxicity and improved their quality of life. Critical to these advances has been the recognition that all breast cancers are not the same and the belief that treatment should be tailored so that every patient receives the best chance of survival with the least morbidity. New insights into the genomic heterogeneity of breast cancer offer the prospect for improved outcomes for patients with breast cancer by further personalization of breast cancer care. |
| Databáze: | OpenAIRE |
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