| Popis: |
In a previous paper (Corkill and Tiges, 1933) evidence was given that the increase in strength of contraction which occurs in fatiguing skeletal muscle when its sympathetic nerves are stimulated (Orbeli’s effect) exhibits certain features which point to a humoral mode of origin. This humoral action is suggested (i) by the presence of the effect long after sympathetic stimulation has ceased, (ii) by an increase in latent period of onset of successive rsponses when they progressively weaken, (iii) by the fact that the effect may be reproduced by appropriate treatment with adrenaline. A purely vascular origin of the effect having been excluded, the humoral interpretation would seem to offer a means of recording the occurrence of the phenomenon with the apparent absence of a direct sympathetic supply to the muscle tissue; for the only sympathetic nerves in muscle whose existence is beyond dispute are those its blood vessels. |
