| Autor: |
Pradeepkumar Prajapati, R Galib, Mukesh Nariya, B R Bhagyalakshmi |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
The Journal of Phytopharmacology. 5:50-52 |
| ISSN: |
2320-480X |
| DOI: |
10.31254/phyto.2016.5203 |
| Popis: |
Introduction: Kajjali is considered as the base in maximum Rasa Yogas (Herbo-mineral formulations). Shwasakuthara Rasa (SKR) is a well-known herbo-mineral formulation indicated in different kinds of Shwasa (respiratory diseases) and Kasa (cough) having Kajjali as a base ingredient. The present study is to evaluate the acute toxicity and anti-tussive activity of SKR one prepared with Kajjali (SKR1) and another without Kajjali (SKR2) in sulphur dioxide induced cough model in albino mice. Materials and Methods: Acute toxicity study was carried as per the OECD 425 guideline in wistar female rats. Anti-tussive activity was carried out against sulphur dioxide-induced cough reflex in mice. Results: Animals did not manifest any signs of toxicity and mortality at the dose of 2000mg/kg body weight, orally. Both test drugs (32.5 mg/kg, po) showed significant reduction in cough reflexes compared with control. SKR1 showed pronounced anti-tussive activity followed by SKR2 when compared to control group. Conclusion: The presence of Kajjali in the formulation is safe on acute administration and further enhances anti-tussive activity of the formulation may be due to increasing bioavailability of Ayurvedic formulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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